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Molecular mechanisms of lymphatic vascular development.

PostPosted: Fri May 25, 2007 2:06 am
by patoco
Molecular mechanisms of lymphatic vascular development.

Cell Mol Life Sci. 2007 Apr 27

Makinen T, Norrmen C, Petrova TV.
Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields,
London, WC2A 3PX, UK.

Keywords. Lymphangiogenesis - vascular remodeling - PROX1 - VEGFR-3 - FOXC2 - Ephs/ephrins

Lymphatic vasculature has recently emerged as a prominent area in
biomedical research because of its essential role in the maintenance
of normal fluid homeostasis and the involvement in pathogenesis of
several human diseases, such as solid tumor metastasis, inflammation
and lymphedema. Identification of lymphatic endothelial specific
markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. In this review we
summarize recent advances in the field and discuss how this knowledge
as well as use of model organisms, such as zebrafish and Xenopus,
should allow further in depth analysis of the lymphatic vascular


Pat O'Connor
Lymphedema People